Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck–cyclisation–elimination sequence
نویسندگان
چکیده
منابع مشابه
An expedient route to substituted furans via olefin cross-metathesis.
The olefin cross-metathesis (CM) reaction is used extensively in organic chemistry and represents a powerful method for the selective synthesis of differentially substituted alkene products. Surprisingly, efforts to integrate this remarkable process into strategies for aromatic and heteroaromatic construction have not been reported. Such structures represent key elements of the majority of smal...
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RCM can be used to make aromatic heterocycles, namely pyridines and, for the first time, pyridazines; the key step after RCM involves elimination of sulfinate to provide the aromatic system.
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Preparation of new types of trisubstituted oxazoles is realized via chemoselective O-acylations and intramolecular Wittig reactions with ester functionalities using in situ formed phosphorus ylides as key intermediates. A plausible reaction mechanism for this undiscovered chemistry is also proposed based on the existence of expected and rearranged isomeric oxazoles.
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Cellulose sulfuric acid is an efficient metal-free catalyst for the synthesis of 1,3,5-trisubstituted pyrazoles via the condensation of 1,3-diketones and hydrazines. The reaction was carried out in Solvent-free condition at room temperature and the products were isolated in good to excellent yields. Mild reaction conditions, as well as ease of operation and workup are some advantages of the pro...
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The napyradiomycins are an intriguing family of halogenated natural products with activity against several tumor cell lines as well as some of the worst bacterial strains known to humanity, including methicillin-resistant Staphylococcus aureas and vancomycin-resistant strains of Enterococcus faecium. This communication delineates the first asymmetric total synthesis of (-)-napyradiomycin A1 by ...
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2011
ISSN: 1359-7345,1364-548X
DOI: 10.1039/c1cc14257g